This medicine comes with a patient information leaflet. Read and follow these instructions carefully before you start using sildenafil and each time you get a refill of your medicine. Ask your doctor if you have any questions.
PDE5 inhibitors work by blocking the enzymes that inhibit blood flow in parts of your body. When men with erectile dysfunction take sildenafil, it helps the arteries in their penis expand to allow more blood flow and firmer, longer-lasting erections. When people PAH take sildenafil, the medication helps open up any narrowed arteries in their lungs and improve their circulation during periods of exercise.
Sildenafil (also called sildenafil citrate) is a prescription drug used to treat erectile dysfunction in men and pulmonary arterial hypertension (PAH) in men and women. It works by blocking the enzymes that make it more difficult for blood vessels to dilate and circulate freely through your body.
In 1998, Pfizer patented sildenafil under the brand name Viagra and began selling it to consumers worldwide. In 2005, the FDA re-approved sildenafil to treat people with PAH. To make sure that everyone could tell the difference between the two drugs, Pfizer marketed this new use of sildenafil under the name Revatio.
If you suffer from heart problems or have a history of heart attack, heart failure, or other cardiovascular issues, your healthcare provider may prescribe a lower dose of sildenafil to avoid any adverse effects from taking the drug.
Sildenafil also comes with a risk of drug interactions with certain pharmaceuticals, particularly nitrates, nitroglycerin, or alpha-blockers. If you take any of these, sildenafil may not be right for you.
Patients who have experienced a heart attack, stroke, irregular heartbeat, or low blood pressure should be very careful before taking sildenafil. Although it can still be therapeutic for certain people with stabilized heart conditions, it can cause dangerously low blood pressure for others, particularly when combined with nitrates (glyceryl trinitrate (GTN), isosorbide dinitrate, and isosorbide mononitrate). Talk to your doctor about taking a low dose of sildenafil and whether that will help you avoid potential complications.
Sildenafil can also cause permanent vision loss in people with certain pre-existing eye conditions. If you are at risk of non-arteritic anterior ischemic optic neuropathy (NAION) or retinitis pigmentosa, talk to your doctor before taking sildenafil or any other ED medication.
Lastly, never take more sildenafil than a doctor prescribes or combine it with street drugs like amyl nitrite (poppers). Increasing your dosage or combining it with other drugs can raise the likelihood of experiencing a severe side effect.
The amount of time that sildenafil affects someone depends on their weight, age, and other health factors, but the pill usually wears off after 4-6 hours. Note that your erection should never last more than four hours. If it does, seek medical treatment. You are at risk of developing priapism, a condition that can damage your penis if you do not see a doctor.
Sildenafil is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works.
Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sildenafil in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving sildenafil.
It is important that you tell all of your doctors that you take sildenafil. If you need emergency medical care for a heart problem, it is important that your doctor knows when you last took sildenafil.
If you take sildenafil for pulmonary arterial hypertension, do not take Viagra or other PDE5 inhibitors, including tadalafil (Cialis) or vardenafil (Levitra). Viagra also contains sildenafil. If you take too much sildenafil or take it together with these medicines, the chance for side effects will be higher.
If you already use medicine for high blood pressure (hypertension), sildenafil could make your blood pressure go too low. Call your doctor right away if you have blurred vision, confusion, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, sweating, or unusual tiredness or weakness.
Sildenafil (brand name Revatio; see Important Safety Information) is typically used as a treatment for a lung condition called pulmonary arterial hypertension (PAH). The medication works by relaxing blood vessels to improve blood flow. Consequently, sildenafil can be used to treat erectile dysfunction for the same reason. Improved blood flow to the penis means harder erections for more satisfying sex.
The FDA approved sildenafil 20 mg for the treatment of PAH and the 25 mg, 50 mg, and 100 mg dosages for the treatment of erectile dysfunction. Because sildenafil is the active ingredient in Viagra, the 20 mg dose can be prescribed off-label to treat ED (DailyMed, 2020).
If your healthcare provider is considering prescribing sildenafil for the treatment of ED, the traditional starting dose is 50 mg. But this dose might not be effective for everyone, and a higher dose may mean a higher risk of side effects for some people. Since generic Viagra is only available in dosages of 25 mg, 50 mg, and 100 mg, the prescribing options are limited. Clinicians can opt to prescribe 20 mg sildenafil (or multiples of 20 mg) to give their patients a more precise dose.
Money is also a consideration when deciding between Viagra or sildenafil. Brand name Viagra is expensive and can cost upwards of $70 per dose. Opting for the generic Viagra (sildenafil) lowers the price, and opting for generic Revatio in 20 mg increments may be an even more pocket-friendly option.
Viagra (sildenafil) is not available over the counter, but you can consult with a healthcare provider in person or online to get a prescription. There are more options available than ever to receive Viagra discreetly in the mail, if this is a concern.
Side effects associated with sildenafil and other ED medications include headache, facial flushing, nasal congestion, stomach upset, backache, and (rarely) temporary impaired color vision. If you experience vision changes, chest pain, or priapism (an erection lasting more than four hours) seek medical attention immediately.
Sildenafil and other PDE5 inhibitors should never be taken with nitrates or nitrites. These include prescription medications used to treat chest pain and a recreational drug called poppers. Taking sildenafil with nitrates can cause a dangerous drop in blood pressure that could be fatal.
Roman-affiliated doctors may prescribe VIAGRA or generic VIAGRA for the treatment of premature ejaculation (PE), if they believe in their medical judgment that it is an appropriate course of treatment. While this is not an FDA-approved use of the drug, the American Urological Association has included the use of sildenafil citrate in the treatment of PE in its Guideline on the Pharmacologic Management of Premature Ejaculation.
Sildenafil contains the same medicine as VIAGRA (sildenafil citrate), which is used to treat erectile dysfunction (impotence) and REVATIO, which is used to treat pulmonary hypertension. Do not take sildenafil with VIAGRA, REVATIO, or other PDE5 inhibitors.
Sildenafil citrate 20 mg tablets are the generic version of REVATIO, prescription medicine used to treat pulmonary hypertension. Sildenafil citrate is also the active ingredient in VIAGRA (sildenafil citrate 25 mg, 50 mg, and 100 mg tablets), which is FDA approved to treat erectile dysfunction (ED).
Roman-affiliated doctors may prescribe sildenafil citrate 20 mg tablets for the treatment of ED or premature ejaculation (PE), if they believe in their medical judgment that it is an appropriate course of treatment.
In a previous study, 6-minute walk distance (6MWD) improvement with sildenafil was not dose dependent at the 3 doses tested (20, 40, and 80 mg 3 times daily [TID]). This study assessed whether lower doses were less effective than the approved 20-mg TID dosage.
Treatment-naive patients with pulmonary arterial hypertension were randomized to 12 weeks of double-blind sildenafil 1, 5, or 20 mg TID; 12 weeks of open-label sildenafil 20 mg TID followed. Changes from baseline in 6-minute walk distance (6MWD) for sildenafil 1 or 5 mg versus 20 mg TID were compared using a Williams test. Hemodynamics, functional class, and biomarkers were assessed.
Pulmonary arterial hypertension (PAH) is a fatal disease in which increasing pulmonary vascular resistance ultimately culminates in right ventricular failure and death [1, 2]. The phosphodiesterase type 5 (PDE5) inhibitor sildenafil is approved to treat adult patients with PAH ; pediatric use is approved in the European Union.
In the 12-week, randomized, double-blind, SUPER-1 study , statistically significant improvements in 6-minute walk distance (6MWD) were observed with sildenafil versus placebo in treatment-naive patients at all 3 tested doses (20, 40, and 80 mg 3 times daily [TID]); improvements were similar among groups and did not appear to be dose related. However, hemodynamic parameters, including mean pulmonary arterial pressure (mPAP), cardiac index, and pulmonary vascular resistance index (PVRI), appeared to improve dose dependently with sildenafil treatment. Sildenafil 20 mg TID appeared to reach the plateau of the dose-response curve for 6MWD  and was confirmed by subsequent population pharmacokinetic and pharmacodynamic analysis . 59ce067264